Article
The intracellular tyrosine kinase Brk sensitizes non-transformed cells to inducers of apoptosis.
Cell cycle (Georgetown, Tex.) - 1 Sept 2005
Haegebarth Andrea, Nunez Rafael, Tyner Angela L
Abstract excerpt
The intracellular tyrosine kinase Brk is expressed in regenerating epithelial tissues with highest levels in the gastrointestinal tract and skin. In these tissues, Brk is restricted to epithelial cells that are exiting the cell cycle and undergoing terminal differentiation. While not expressed in mammary gland, Brk expression is often induced in primary breast tumors and breast tumor cell lines. To identify...
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