Article
Arrest of the cell cycle by the tumour-suppressor BRCA1 requires the CDK-inhibitor p21WAF1/CiP1.
Nature - 11 Sept 1997
Somasundaram K, Zhang H, Zeng Y X, Houvras Y, Peng Y, Zhang H, Wu G S, Licht J D, Weber B L, El-Deiry W S
Abstract excerpt
Much of the predisposition to hereditary breast and ovarian cancer has been attributed to inherited defects in the BRCA1 tumour-suppressor gene. The nuclear protein BRCA1 has the properties of a transcription factor, and can interact with the recombination and repair protein RAD51. Young women wi...
Topics
- Animals
- BRCA1 Protein
- COS Cells
- Cell Cycle
- Cyclin-Dependent Kinase Inhibitor p21
- Cyclin-Dependent Kinases
- Cyclins
- DNA
- Enzyme Inhibitors
- Gene Expression Regulation
- Genes, Tumor Suppressor
- Green Fluorescent Proteins
- HeLa Cells
- Humans
- Luminescent Proteins
- Mice
- Mutation
- Promoter Regions, Genetic