Article
Arrest of the cell cycle by the tumour-suppressor BRCA1 requires the CDK-inhibitor p21WAF1/CiP1.
Nature - 11 Sept 1997
Somasundaram K, Zhang H, Zeng Y X, Houvras Y, Peng Y, Zhang H, Wu G S, Licht J D, Weber B L, El-Deiry W S
Abstract excerpt
Much of the predisposition to hereditary breast and ovarian cancer has been attributed to inherited defects in the BRCA1 tumour-suppressor gene. The nuclear protein BRCA1 has the properties of a transcription factor, and can interact with the recombination and repair protein RAD51. Young women with germline alterations in BRCA1 develop breast cancer at rates 100-fold higher than the general population, and...
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