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Alterations in cell growth and signaling in ErbB3 binding protein-1 (Ebp1) deficient mice

1 Dec 2008

Abstract excerpt

BACKGROUND: The ErbB3 binding protein-1 (Ebp1) belongs to a family of DNA/RNA binding proteins implicated in cell growth, apoptosis and differentiation. However, the physiological role of Ebp1 in the whole organism is not known. Therefore, we generated Ebp1-deficient mice carrying a gene trap insertion in intron 2 of the Ebp1 (pa2g4) gene. RESULTS: Ebp1-/- mice were on average 30% smaller than wild type and...

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PMID: 19094237
DOI: 10.1186/1471-2121-9-69

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