Article
Induction of apoptosis in Mv1Lu cells by expression of competitive RB1 mutants.
Oncogene - 28 Aug 1997
Whitaker L L, Hansen M F
Abstract excerpt
The Retinoblastoma tumor suppressor gene (RB1) plays a role in a variety of human cancers. Experimental analyses have indicated that the protein product of the RB1 gene (pRb) plays a role in cell cycle regulation. pRb function is dependent on its ability to bind to cellular factors, which is facilitated by multiple protein binding domains within pRb. Mutations within these domains which eliminate the ability of...
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