Article
Induction of apoptosis in Mv1Lu cells by expression of competitive RB1 mutants.
Oncogene - 28 Aug 1997
Whitaker L L, Hansen M F
Abstract excerpt
The Retinoblastoma tumor suppressor gene (RB1) plays a role in a variety of human cancers. Experimental analyses have indicated that the protein product of the RB1 gene (pRb) plays a role in cell cycle regulation. pRb function is dependent on its ability to bind to cellular factors, which is faci...
Topics
- Animals
- Apoptosis
- Binding, Competitive
- Cell Line
- Epithelial Cells
- Gene Expression Regulation, Neoplastic
- Genes, Retinoblastoma
- Lung
- Mink
- Mutagenesis, Insertional
- Phenotype
- Retinoblastoma Protein
- Transfection