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Article

CDK1 inhibition sensitizes normal cells to DNA damage in a cell cycle dependent manner

18 Jun 2018

Abstract excerpt

Cyclin-dependent kinase 1 (CDK1) orchestrates the transition from the G2 phase into mitosis and as cancer cells often display enhanced CDK1 activity, it has been proposed as a tumor specific anti-cancer target. Here we show that the effects of CDK1 inhibition are not restricted to tumor cells but can also reduce viability in non-cancer cells and sensitize them to radiation in a cell cycle dependent manner....

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PMID: 30045664
DOI: 10.1080/15384101.2018.1491236

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