Failure of RB1 to reverse the malignant phenotype of human tumor cell lines.

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Article

Failure of RB1 to reverse the malignant phenotype of human tumor cell lines.

Cancer research - 1 Feb 1992

Muncaster M M, Cohen B L, Phillips R A, Gallie B L

Abstract excerpt

In addition to retinoblastoma and osteosarcoma, mutation of both alleles of the RB1 gene occurs frequently in several other types of tumors. In order to evaluate the role of RB1 in cancer, the wild type RB1 gene was introduced into the RB1-deleted breast cancer cell line MDA-468-S4 and retinoblastoma cell lines WERI-Rb1 and Y-79. The RB1 complementary DNA was under control of the inducible murine metallothionein...

Topics

Animals
Breast Neoplasms
Cell Cycle
Cell Division
Cell Line
Chromosome Deletion
Eye Neoplasms
Female
Genes, Retinoblastoma
HeLa Cells
Humans
Metallothionein

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Phenotype

Plasmids

Promoter Regions, Genetic

Recombinant Fusion Proteins

Restriction Mapping

Retinoblastoma

Source

Open in PubMed

Identifiers

PMID: 1732054

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1732054-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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