Article
Tumor suppressor p53 is required to modulate BRCA1 expression.
Molecular and cellular biology - 1 Oct 2000
Arizti P, Fang L, Park I, Yin Y, Solomon E, Ouchi T, Aaronson S A, Lee S W
Abstract excerpt
Individuals carrying mutations in BRCA1 or p53 genes are predisposed to a variety of cancers, and both tumor suppressor genes have been implicated in DNA damage response pathways. We have analyzed a possible functional link between p53 and BRCA1 genes. Here we show that BRCA1 expression levels are down-regulated in response to p53 induction in cells that undergo either growth arrest, senescence, or apoptosis....
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