Article
Tumor suppressor p53 is required to modulate BRCA1 expression.
Molecular and cellular biology - 1 Oct 2000
Arizti P, Fang L, Park I, Yin Y, Solomon E, Ouchi T, Aaronson S A, Lee S W
Abstract excerpt
Individuals carrying mutations in BRCA1 or p53 genes are predisposed to a variety of cancers, and both tumor suppressor genes have been implicated in DNA damage response pathways. We have analyzed a possible functional link between p53 and BRCA1 genes. Here we show that BRCA1 expression levels are down-regulated in response to p53 induction in cells that undergo either growth arrest, senescence, or apoptosis....
Topics
- Animals
- BRCA1 Protein
- Cell Cycle
- Cells, Cultured
- DNA Damage
- Down-Regulation
- Gene Expression Regulation
- Genes, Reporter
- Humans
- Mice
- Mutation
- Promoter Regions, Genetic
- RNA, Messenger
- Repressor Proteins
- Transfection
- Tumor Suppressor Protein p53