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Article

The specific role of pRb in p16<sup>INK4A</sup>-mediated arrest of normal and malignant human breast cells

1 Mar 2012

Abstract excerpt

RB family proteins pRb, p107 and p130 have similar structures and overlapping functions, enabling cell cycle arrest and cellular senescence. pRb, but not p107 or p130, is frequently mutated in human malignancies. In human fibroblasts acutely exposed to oncogenic ras, pRb has a specific role in suppressing DNA replication, and p107 or p130 cannot compensate for the loss of this function; however, a second...

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PMID: 22333593
DOI: 10.4161/cc.11.5.19492

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