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Article

BRCA1 shifts p53-mediated cellular outcomes towards irreversible growth arrest.

Oncogene - 12 Jun 2003

Ongusaha Pat P, Ouchi Toru, Kim Kyung-Tae, Nytko Emily, Kwak Jennifer C, Duda Rosemary B, Deng Chu-Xia, Lee Sam W

Abstract excerpt

The tumor suppressor protein BRCA1 has been shown to enhance p53 transcription, whereas activated p53 represses BRCA1 transcription. To further understand the functional interaction of these proteins, we investigated the role of BRCA1 in p53-induced phenotypes. We found that BRCA1 when subjected to forced expression acts synergistically with wild-type p53, resulting in irreversible growth arrest, as shown by VhD...

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Source

Identifiers

PMID: 12802282
DOI: 10.1038/sj.onc.1206439

Genes

BRCA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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