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Article

Relative power of linkage and transmission disequilibrium test strategies to detect non-HLA linked coeliac disease susceptibility genes.

Gut - 1 Nov 1999

Bevan S, Popat S, Houlston R S

Abstract excerpt

BACKGROUND: Susceptibility to coeliac disease is genetically determined by possession of specific HLA DQ alleles, acting in concert with one or more non-HLA linked genes. The pattern of familial risk is most parsimonious with a multiplicative model for the interaction between these two classes of genes. Haplotype sharing probabilities across the HLA region in affected sibling pairs suggest that genes within the...

Topics

Alleles
Celiac Disease
Genes, MHC Class I
Genetic Linkage
Genetic Markers
Genetic Predisposition to Disease
Heterozygote
Humans
Linkage Disequilibrium
Risk
Sample Size

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Identifiers

PMID: 10517901
DOI: 10.1136/gut.45.5.668
PMCID: PMC1727705

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-10517901-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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