Article
Variation in the CTLA4/CD28 gene region confers an increased risk of coeliac disease.
Annals of human genetics - 1 Mar 2002
Popat S, Hearle N, Hogberg L, Braegger C P, O'Donoghue D, Falth-Magnusson K, Holmes G K T, Howdle P D, Jenkins H, Johnston S, Kennedy N P, Kumar P J, Logan R F A, Marsh M N, Mulder C J, Torinsson Naluai A, Sjoberg K, Stenhammar L, Walters J R F, Jewell D P, Houlston R S
Abstract excerpt
Susceptibility to coeliac disease involves HLA and non-HLA-linked genes. The CTLA4/CD28 gene region encodes immune regulatory T-cell surface molecules and is a strong candidate as a susceptibility locus. We evaluated CTLA4/CD28 in coeliac disease by genetic linkage and association and combined our findings with published studies through a meta-analysis. 116 multiplex families were genotyped across CTLA4/CD28...
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