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Article

Linkage of Crohn's disease to the major histocompatibility complex region is detected by multiple non-parametric analyses.

Gut - 1 Apr 1999

Yang H, Plevy S E, Taylor K, Tyan D, Fischel-Ghodsian N, McElree C, Targan S R, Rotter J I

Abstract excerpt

BACKGROUND: There is evidence for genetic susceptibility to Crohn's disease, and a tentative association with tumour necrosis factor (TNF) and HLA class II alleles. AIMS: To examine the potential of genetic linkage between Crohn's disease and the MHC region on chromosome 6p. METHODS: TNF microsatellite markers and, for some families, additional HLA antigens were typed for 323 individuals from 49 Crohn's disease...

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Share to Chromosomes, Human, Pair 6
Share to Crohn Disease

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Share to Histocompatibility Testing

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Source

Open in PubMed Open full text

Identifiers

PMID: 10075959
DOI: 10.1136/gut.44.4.519
PMCID: PMC1727474

Genes

TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

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Linkage of Crohn's disease to the major histocompatibility complex region is detected by multiple non-parametric analyses.PMID 10075959Read ↗

Linkage of inflammatory bowel disease to human chromosome 6p.Semantic proximity Read ↗

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Contribution of genes of the major histocompatibility complex to susceptibility and disease phenotype in inflammatory bowel disease.Semantic proximity Read ↗

Genetic analysis in Italian families with inflammatory bowel disease supports linkage to the IBD1 locus--a GISC study.Semantic proximity Read ↗

On the genetic involvement of apoptosis-related genes in Crohn's disease as revealed by an extended association screen using 245 markers: no evidence for new predisposing factors.Semantic proximity Read ↗

Whole-genome linkage analysis of rheumatoid arthritis susceptibility loci in 252 affected sibling pairs in the United Kingdom.Semantic proximity Read ↗

Tumor necrosis factor microsatellites define a Crohn's disease-associated haplotype on chromosome 6.Semantic proximity Read ↗

Additional evidence of linkage between Crohn's disease and a putative locus on chromosome 12.Semantic proximity Read ↗

Mapping of a susceptibility locus for Crohn's disease on chromosome 16.Semantic proximity Read ↗

Genetic analysis of inflammatory bowel disease in a large European cohort supports linkage to chromosomes 12 and 16.Semantic proximity Read ↗

International collaboration provides convincing linkage replication in complex disease through analysis of a large pooled data set: Crohn disease and chromosome 16.Semantic proximity Read ↗

Candidate genes colocalized to linkage regions in inflammatory bowel disease.Semantic proximity Read ↗

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