Contribution of the MHC region to the familial risk of coeliac disease

doi:10.1136/jmg.36.9.687

Article

Contribution of the MHC region to the familial risk of coeliac disease

1 Sept 1999

Abstract excerpt

Susceptibility to coeliac disease is genetically determined by possession of specific HLA-DQ alleles, acting in concert with one or more non-HLA linked genes. The pattern of risk seen in sibs and twins in coeliac disease is most parsimonious with a multiplicative model for the interaction between the two classes of genes. Based on a sib recurrence risk for coeliac disease of 10% and a population prevalence of...

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