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Article

The SIR2/3/4 complex and SIR2 alone promote longevity in Saccharomyces cerevisiae by two different mechanisms.

Genes & development - 1 Oct 1999

Kaeberlein M, McVey M, Guarente L

Abstract excerpt

The SIR genes are determinants of life span in yeast mother cells. Here we show that life span regulation by the Sir proteins is independent of their role in nonhomologous end joining. The short life span of a sir3 or sir4 mutant is due to the simultaneous expression of a and alpha mating-type information, which indirectly causes an increase in rDNA recombination and likely increases the production of...

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Identifiers

PMID: 10521401
DOI: 10.1101/gad.13.19.2570
PMCID: PMC317077

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Source receipt: pubmed, retrieved 7 Sept 2026.

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