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Article

Changes of telomere length cause reciprocal changes in the lifespan of mother cells in Saccharomyces cerevisiae.

Proceedings of the National Academy of Sciences of the United States of America - 2 Sept 1997

Austriaco N R, Guarente L P

Abstract excerpt

Budding yeast cells divide asymmetrically, giving rise to a mother and its daughter. Mother cells have a limited division potential, called their lifespan, which ends in proliferation-arrest and lysis. In this report we mutate telomerase in Saccharomyces cerevisiae to shorten telomeres and show that, rather than shortening lifespan, this leads to a significant extension in lifespan. This extension requires the...

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Identifiers

PMID: 9275199
DOI: 10.1073/pnas.94.18.9768
PMCID: PMC23265

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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