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Article

Changes of telomere length cause reciprocal changes in the lifespan of mother cells in Saccharomyces cerevisiae.

Proceedings of the National Academy of Sciences of the United States of America - 2 Sept 1997

Austriaco N R, Guarente L P

Abstract excerpt

Budding yeast cells divide asymmetrically, giving rise to a mother and its daughter. Mother cells have a limited division potential, called their lifespan, which ends in proliferation-arrest and lysis. In this report we mutate telomerase in Saccharomyces cerevisiae to shorten telomeres and show t...

Topics

Cell Survival
Fungal Proteins
Genome, Fungal
Mutation
Saccharomyces cerevisiae
Silent Information Regulator Proteins, Saccharomyces cerevisiae
Telomere
Trans-Activators

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 9275199
DOI: 10.1073/pnas.94.18.9768
PMCID: PMC23265

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9275199-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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