Article
Mutation in the silencing gene SIR4 can delay aging in S. cerevisiae.
Cell - 10 Feb 1995
Kennedy B K, Austriaco N R, Zhang J, Guarente L
Abstract excerpt
Aging in S. cerevisiae is exemplified by the fixed number of cell divisions that mother cells undergo (termed their life span). We have exploited a correlation between life span and stress resistance to identify mutations in four genes that extend life span. One of these, SIR4, encodes a component of the silencing apparatus at HM loci and telomeres. The sir4-42 mutation extends life span by more than 30% and is...
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