Loss of transcriptional silencing causes sterility in old mother cells of S. cerevisiae.

doi:10.1016/s0092-8674(00)81038-7

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Article

Loss of transcriptional silencing causes sterility in old mother cells of S. cerevisiae.

Cell - 23 Feb 1996

Smeal T, Claus J, Kennedy B, Cole F, Guarente L

Abstract excerpt

We show that sterility is an aging-specific phenotype in S. cerevisiae and, by genetic and physical means, demonstrate that this phenotype results from a loss of silencing in most old cells by the SIR complex at the HM loci. This loss of silencing is specific because transcription of genes, such...

Topics

Base Sequence
Cell Separation
Cellular Senescence
Gene Expression Regulation
Immunomagnetic Separation
Molecular Sequence Data
Phenotype
Saccharomyces cerevisiae
Transcription, Genetic

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