Article
The mitogen-activated protein kinase pathway inhibits ceramide-induced terminal differentiation of a human monoblastic leukemia cell line, U937.
Journal of immunology (Baltimore, Md. : 1950) - 1 Aug 1998
Ragg S J, Kaga S, Berg K A, Ochi A
Abstract excerpt
This communication describes an extracellular signal-regulated kinase kinase (MEK)-dependent signal transduction pathway that prevents the terminal differentiation of a hemopoietic cell line. Both PMA and the cell-permeable ceramide, C2-ceramide, caused differentiation of U937 cells, but with dis...
Topics
- Calcium-Calmodulin-Dependent Protein Kinases
- Cell Cycle
- Cell Differentiation
- Cyclin-Dependent Kinase Inhibitor p21
- Cyclins
- Enzyme Activation
- Humans
- Leukemia, Monocytic, Acute
- MAP Kinase Kinase 1
- Mitogen-Activated Protein Kinase Kinases
- Phenotype
- Phosphorylation
- Protein Serine-Threonine Kinases
- Protein-Tyrosine Kinases
- Retinoblastoma Protein
- Signal Transduction
- Sphingosine
- Tetradecanoylphorbol Acetate