Article
A lineage-specific protein kinase crucial for myeloid maturation.
Proceedings of the National Academy of Sciences of the United States of America - 22 Dec 1998
Semizarov D, Glesne D, Laouar A, Schiebel K, Huberman E
Abstract excerpt
To identify genes involved in macrophage development, we used the differential display technique and compared the gene expression profiles for human myeloid HL-60 leukemia cell lines susceptible and resistant to macrophage maturation. We identified a gene coding for a protein kinase, protein kina...
Topics
- Calcitriol
- Cell Differentiation
- DNA-Binding Proteins
- Gene Expression Regulation, Enzymologic
- Gene Expression Regulation, Neoplastic
- Genetic Variation
- Granulocytes
- HL-60 Cells
- Humans
- Lymphocytes
- Macrophage Colony-Stimulating Factor
- Macrophages
- Monocytes
- Nuclear Proteins
- Oligodeoxyribonucleotides
- Oligodeoxyribonucleotides, Antisense
- Organ Specificity
- Protein Serine-Threonine Kinases