Article
K562 cells resistant to phorbol 12-myristate 13-acetate-induced growth arrest: dissociation of mitogen-activated protein kinase activation and Egr-1 expression from megakaryocyte differentiation.
Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research - 1 Sept 2000
Shelly C, Petruzzelli L, Herrera R
Abstract excerpt
The K562 cell line undergoes megakaryocytic differentiation in response to phorbol 12-myristate 13-acetate (PMA) stimulation. This event correlates with mitogen-activated protein kinase activation, cell cycle arrest, and expression of the Egr-1 transcription factor. We have isolated K562 cells that are resistant to the growth-inhibitory action of PMA. Molecular characterization demonstrates that PMA resistance is...
Topics
- Animals
- Cell Cycle
- Cell Differentiation
- DNA-Binding Proteins
- Drug Resistance, Neoplasm
- Early Growth Response Protein 1
- Humans
- Immediate-Early Proteins
- K562 Cells
- Leukemia, Megakaryoblastic, Acute
- Megakaryocytes
- Mitogen-Activated Protein Kinases