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Article

Tescalcin is an essential factor in megakaryocytic differentiation associated with Ets family gene expression

25 Aug 2007

Abstract excerpt

We show here that the process of megakaryocytic differentiation requires the presence of the recently discovered protein tescalcin. Tescalcin is dramatically upregulated during the differentiation and maturation of primary megakaryocytes or upon PMA-induced differentiation of K562 cells. This upregulation requires sustained signaling through the ERK pathway. Overexpression of tescalcin in K562 cells initiates...

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PMID: 17717601
DOI: 10.1172/jci27465

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