Induction of plasminogen activator inhibitor type 2 expression during differentiation of human K562 cells towards a macrophage phenotype.

doi:10.1139/o90-196

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Article

Induction of plasminogen activator inhibitor type 2 expression during differentiation of human K562 cells towards a macrophage phenotype.

Biochemistry and cell biology = Biochimie et biologie cellulaire - 1 Dec 1990

Rehemtulla A, Arndt A, Hart D A

Abstract excerpt

Human K562 cells, a multipotential cell line of hematopoietic origin, were found to differentiate towards a macrophage-like cell when incubated in the presence of phorbol myristate acetate (PMA). Differentiation was accompanied by the expression and secretion of a plasminogen activator inhibitor (PAI). Incubation of the cells in the presence of other agents (dimethyl sulfoxide, retinoic acid, vitamin D3) capable...

Topics

Base Sequence
Cell Differentiation
Cholecalciferol
DNA Probes
Dimethyl Sulfoxide
Gene Expression Regulation, Neoplastic
Hematopoietic Stem Cells
Humans
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Macrophages

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Molecular Sequence Data

Neoplasm Proteins

Neoplastic Stem Cells

Phenotype

Plasminogen Activators

Plasminogen Inactivators

Tetradecanoylphorbol Acetate

Tretinoin

Source

Open in PubMed

Identifiers

PMID: 1964793
DOI: 10.1139/o90-196

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1964793-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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