Article
Rescue of high expression beta-tropomyosin transgenic mice by 5-propyl-2-thiouracil. Regulating the alpha-myosin heavy chain promoter.
The Journal of biological chemistry - 8 Oct 1999
Prabhakar R, Boivin G P, Hoit B, Wieczorek D F
Abstract excerpt
Tropomyosin is an essential component of the sarcomeric thin filament in striated muscle that participates in the regulation of muscle contraction through Ca(2+)-mediated activation. The two predominant tropomyosin isoforms expressed in striated muscle are alpha- and beta-tropomyosin, which exhibit an 86% amino acid identity between themselves. Previous studies by our laboratory utilized a transgenic mouse system...
Topics
- Animals
- Down-Regulation
- Gene Expression Regulation
- Heart Atria
- Heart Defects, Congenital
- Heart Function Tests
- Mice
- Mice, Transgenic
- Myosin Heavy Chains
- Myosins
- Organ Size
- Phenotype
- Promoter Regions, Genetic
- Propylthiouracil
- RNA, Messenger
- Tropomyosin