Article
Mouse model of a familial hypertrophic cardiomyopathy mutation in alpha-tropomyosin manifests cardiac dysfunction.
Circulation research - 9 Jul 1999
Muthuchamy M, Pieples K, Rethinasamy P, Hoit B, Grupp I L, Boivin G P, Wolska B, Evans C, Solaro R J, Wieczorek D F
Abstract excerpt
To investigate the functional consequences of a tropomyosin (TM) mutation associated with familial hypertrophic cardiomyopathy (FHC), we generated transgenic mice that express mutant alpha-TM in the adult heart. The missense mutation, which results in the substitution of asparagine for aspartic acid at amino acid position 175, occurs in a troponin T binding region of TM. S1 nuclease mapping and Western blot...
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