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Article

Mouse model of a familial hypertrophic cardiomyopathy mutation in alpha-tropomyosin manifests cardiac dysfunction.

Circulation research - 9 Jul 1999

Muthuchamy M, Pieples K, Rethinasamy P, Hoit B, Grupp I L, Boivin G P, Wolska B, Evans C, Solaro R J, Wieczorek D F

Abstract excerpt

To investigate the functional consequences of a tropomyosin (TM) mutation associated with familial hypertrophic cardiomyopathy (FHC), we generated transgenic mice that express mutant alpha-TM in the adult heart. The missense mutation, which results in the substitution of asparagine for aspartic a...

Topics

Animals
Calcium
Cardiomyopathy, Hypertrophic
Heart
Homeostasis
Mice
Mice, Transgenic
Mutation
Myocardial Contraction
Myocardium
Tropomyosin

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 10400910
DOI: 10.1161/01.res.85.1.47

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026. Prepared record publication-10400910-2026-08-31.1. Manifest publication-graph-cohort-2026-08-31.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 31 Aug 2026.

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