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Article

The role of tropomyosin in the regulation of myocardial contraction and relaxation.

Pflugers Archiv : European journal of physiology - 1 Apr 2003

Wolska Beata M, Wieczorek David M F

Abstract excerpt

Studies over the last 30 years have demonstrated the essential nature of the evolutionarily highly conserved tropomyosin (TM) protein. TM-deficient cells neither function properly nor survive, and mutations within this protein impair severely its function within the sarcomere. The ability to manipulate TM isoform expression genetically within functioning cardiomyocytes and the whole heart has proven essential in...

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Source

Identifiers

PMID: 12690456
DOI: 10.1007/s00424-002-0900-3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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