Article
Tropomyosin 3 expression leads to hypercontractility and attenuates myofilament length-dependent Ca(2+) activation.
American journal of physiology. Heart and circulatory physiology - 1 Oct 2002
Pieples Kathy, Arteaga Grace, Solaro R John, Grupp Ingrid, Lorenz John N, Boivin Greg P, Jagatheesan Ganapathy, Labitzke Erin, DeTombe Pieter P, Konhilas John P, Irving Thomas C, Wieczorek David F
Abstract excerpt
Tropomyosin (TM), an integral component of the thin filament, is encoded by three striated muscle isoforms: alpha-TM, beta-TM, and TPM 3. Although the alpha-TM and beta-TM isoforms are well characterized, less is known about the function of the TPM 3 isoform, which is predominantly found in the slow-twitch musculature of mammals. To determine its functional significance, we ectopically expressed this isoform in...
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