Article
A familial hypertrophic cardiomyopathy alpha-tropomyosin mutation causes severe cardiac hypertrophy and death in mice.
Journal of molecular and cellular cardiology - 1 Oct 2001
Prabhakar R, Boivin G P, Grupp I L, Hoit B, Arteaga G, Solaro R J, Wieczorek D F
Abstract excerpt
Tropomyosin, an essential component of the sarcomere, regulates muscle contraction through Ca(2+)-mediated activation. Familial hypertrophic cardiomyopathy (FHC) is caused by mutations in numerous cardiac sarcomeric proteins, including myosin heavy and light chains, actin, troponin T and I, myosin binding protein C, and alpha-tropomyosin. This study developed transgenic mouse lines that encode an FHC mutation in...
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