Article
Transcriptional enhancer factor 1 disruption by a retroviral gene trap leads to heart defects and embryonic lethality in mice.
Genes & development - 1 Oct 1994
Chen Z, Friedrich G A, Soriano P
Abstract excerpt
We have used a retroviral gene trap in embryonic stem (ES) cells to derive a recessive embryonic lethal mouse strain, ROSA beta-geo5. Mutant embryos display an enlarged pericardial cavity, bradycardia, a dilated fourth ventricle in the brain, and die between embryonic days 11 and 12. Whereas hear...
Topics
- Amino Acid Sequence
- Animals
- Base Sequence
- Cloning, Molecular
- DNA Primers
- DNA, Complementary
- DNA-Binding Proteins
- Embryo, Mammalian
- Female
- Fetal Death
- Genes, Lethal
- Heart Defects, Congenital
- Male
- Mice
- Mice, Mutant Strains
- Molecular Sequence Data
- Mutation
- Nuclear Proteins