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Cardiac transgenesis with the tetracycline transactivator changes myocardial function and gene expression.

Physiological genomics - 16 Jun 2005

McCloskey Diana T, Turnbull Lynne, Swigart Philip M, Zambon Alexander C, Turcato Sally, Joho Shuji, Grossman William, Conklin Bruce R, Simpson Paul C, Baker Anthony J

Abstract excerpt

The cardiac-specific tetracycline-regulated gene expression system (tet-system) is a powerful tool using double-transgenic mice. The cardiac alpha-myosin heavy chain promoter (alphaMHC) drives lifetime expression of a tetracycline-inhibited transcription activator (tTA). Crossing alphaMHC-tTA mice with mice containing a tTA-responsive promoter linked to a target gene yields double-transgenic mice having...

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PMID: 15797971
DOI: 10.1152/physiolgenomics.00016.2005

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