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Article

Long-term rescue of a familial hypertrophic cardiomyopathy caused by a mutation in the thin filament protein, tropomyosin, via modulation of a calcium cycling protein.

Journal of molecular and cellular cardiology - 1 Nov 2011

Gaffin Robert D, Peña James R, Alves Marco S L, Dias Fernando A L, Chowdhury Shamim A K, Heinrich Lynley S, Goldspink Paul H, Kranias Evangelia G, Wieczorek David F, Wolska Beata M

Abstract excerpt

We have recently shown that a temporary increase in sarcoplasmic reticulum (SR) cycling via adenovirus-mediated overexpression of sarcoplasmic reticulum ATPase (SERCA2) transiently improves relaxation and delays hypertrophic remodeling in a familial hypertrophic cardiomyopathy (FHC) caused by a mutation in the thin filament protein, tropomyosin (i.e., α-TmE180G or Tm180). In this study, we sought to permanently...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 21840315
DOI: 10.1016/j.yjmcc.2011.07.026
PMCID: PMC3221410

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PLN

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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