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Article

Rescue of tropomyosin-induced familial hypertrophic cardiomyopathy mice by transgenesis.

American journal of physiology. Heart and circulatory physiology - 1 Aug 2007

Jagatheesan Ganapathy, Rajan Sudarsan, Petrashevskaya Natalia, Schwartz Arnold, Boivin Greg, Arteaga Grace M, Solaro R John, Liggett Stephen B, Wieczorek David F

Abstract excerpt

Familial hypertrophic cardiomyopathy (FHC) is a disease caused by mutations in contractile proteins of the sarcomere. Our laboratory developed a mouse model of FHC with a mutation in the thin filament protein alpha-tropomyosin (TM) at amino acid 180 (Glu180Gly). The hearts of these mice exhibit dramatic systolic and diastolic dysfunction, and their myofilaments demonstrate increased calcium sensitivity. The mice...

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Identifiers

PMID: 17416600
DOI: 10.1152/ajpheart.01341.2006

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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