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Article

An internal domain of beta-tropomyosin increases myofilament Ca(2+) sensitivity.

American journal of physiology. Heart and circulatory physiology - 1 Jul 2009

Jagatheesan Ganapathy, Rajan Sudarsan, Schulz Emily M, Ahmed Rafeeq P H, Petrashevskaya Natalia, Schwartz Arnold, Boivin Greg P, Arteaga Grace M, Wang Tao, Wang Yi-Gang, Ashraf Muhammad, Liggett Stephen B, Lorenz John, Solaro R John, Wieczorek David F

Abstract excerpt

Tropomyosin (TM) is involved in Ca(2+)-mediated muscle contraction and relaxation in the heart. Striated muscle alpha-TM is the major isoform expressed in the heart. The expression of striated muscle beta-TM in the murine myocardium results in a decreased rate of relaxation and increased myofilament Ca(2+) sensitivity. Replacing the carboxyl terminus (amino acids 258-284) of alpha-TM with beta-TM (a troponin...

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Identifiers

PMID: 19429821
DOI: 10.1152/ajpheart.00329.2008
PMCID: PMC2711731

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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