Article
Two different forms of p53 localized differently within cells of urogenital tumours.
Cancer letters - 20 Sept 1999
Benninghoff J, Kartarius S, Teleb Z, Selter H, Unteregger G, Zwergel T, Wullich B, Montenarh M
Abstract excerpt
We analyzed the subcellular localization of p53 in prostate and bladder carcinoma cells. Using laser scanning microscopy and PAb1620, a monoclonal antibody recognizing the wildtype conformation of p53, and another monoclonal antibody directed against the mutant conformation of the protein (PAb240), we found two different subsets of p53 within the same cell. The wildtype subgroup was found in the nucleolus,...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.
