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Article

Presence and location of TP53 mutation determines pattern of CDKN2A/ARF pathway inactivation in bladder cancer.

Cancer research - 1 Dec 1998

Markl I D, Jones P A

Abstract excerpt

Transformation and immortalization require the inactivation of key cell cycle regulatory genes. We examined 19 bladder cancer cell lines derived from 17 patients for alterations in TP53, RB1, CDKN2A, and ARF. Twelve cell lines had a mutation in exons 5-11 of TP53 and, with only one exception, a c...

Topics

DNA Methylation
DNA, Neoplasm
Gene Expression Regulation, Neoplastic
Genes, Retinoblastoma
Genes, p16
Genes, p53
Humans
Mutation
Retinoblastoma Protein
Tumor Cells, Cultured
Tumor Suppressor Protein p53
Urinary Bladder Neoplasms

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 9850064

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9850064-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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