Regulation of bacteriophage lambda development by guanosine 5'-diphosphate-3'-diphosphate.

doi:10.1006/viro.1999.9907

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Article

Regulation of bacteriophage lambda development by guanosine 5'-diphosphate-3'-diphosphate.

Virology - 30 Sept 1999

Slomińska M, Neubauer P, Wegrzyn G

Abstract excerpt

On infection of its host, Escherichia coli, bacteriophage lambda can follow one of two alternative developmental pathways: lytic or lysogenic. Here we demonstrate that the "lysis-versus-lysogenization" decision is influenced by guanosine tetraphosphate (ppGpp), a nucleotide that is synthesized in E. coli cells in response to amino acid or carbon source starvation. We found that the efficiency of lysogenization is...

Topics

ATP-Dependent Proteases
Bacterial Proteins
Bacteriolysis
Bacteriophage lambda
Cyclic AMP
Escherichia coli
Escherichia coli Proteins
Gene Expression Regulation, Bacterial
Gene Expression Regulation, Viral
Genes, Viral
Guanosine Tetraphosphate
Lysogeny
Membrane Proteins
Mutation
Phenotype
Promoter Regions, Genetic
Transcription Factors
Transcription, Genetic

Source

Open in PubMed

Identifiers

PMID: 10502521
DOI: 10.1006/viro.1999.9907

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