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Article

Guanosine 3',5'-bispyrophosphate coordinates global gene expression during glucose-lactose diauxie in Escherichia coli.

Proceedings of the National Academy of Sciences of the United States of America - 14 Feb 2006

Traxler Matthew F, Chang Dong-Eun, Conway Tyrrell

Abstract excerpt

Guanosine 3',5'-bispyrophosphate (ppGpp), also known as "magic spot," has been shown to bind prokaryotic RNA polymerase to down-regulate ribosome production and increase transcription of amino acid biosynthesis genes during the stringent response to amino acid starvation. Because many environmental growth perturbations cause ppGpp to accumulate, we hypothesize ppGpp to have an overarching role in regulating the...

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Identifiers

PMID: 16467149
DOI: 10.1073/pnas.0510995103
PMCID: PMC1413745

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Source receipt: pubmed, retrieved 7 Sept 2026.

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