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Role of (p)ppGpp in antibiotic resistance, tolerance, persistence and survival in Firmicutes

1 Jan 2023

Abstract excerpt

Abstract The stringent response and its signalling nucleotides, pppGpp and ppGpp, have been the subject of intense research since the discovery of (p)ppGpp in 1969. Recent studies have revealed that the downstream events that follow (p)ppGpp accumulation vary among species. Consequently, the stringent response as initially characterized in Escherichia coli largely differs from the response in Firmicutes...

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PMID: 37223729
DOI: 10.1093/femsml/uqad009

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