Article
The Borrelia burgdorferi RelA/SpoT Homolog and Stringent Response Regulate Survival in the Tick Vector and Global Gene Expression during Starvation.
PLoS pathogens - 1 Sept 2015
Drecktrah Dan, Lybecker Meghan, Popitsch Niko, Rescheneder Philipp, Hall Laura S, Samuels D Scott
Abstract excerpt
As the Lyme disease bacterium Borrelia burgdorferi traverses its enzootic cycle, alternating between a tick vector and a vertebrate host, the spirochete must adapt and persist in the tick midgut under prolonged nutrient stress between blood meals. In this study, we examined the role of the stringent response in tick persistence and in regulation of gene expression during nutrient limitation. Nutritionally...
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