Borrelia burgdorferi rel is responsible for generation of guanosine-3'-diphosphate-5'-triphosphate and growth control.

doi:10.1128/IAI.73.8.4972-4981.2005

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Article

Borrelia burgdorferi rel is responsible for generation of guanosine-3'-diphosphate-5'-triphosphate and growth control.

Infection and immunity - 1 Aug 2005

Bugrysheva Julia V, Bryksin Anton V, Godfrey Henry P, Cabello Felipe C

Abstract excerpt

The global transcriptional regulator (p)ppGpp (guanosine-3'-diphosphate-5'-triphosphate and guanosine-3',5'-bisphosphate, collectively) produced by the relA and spoT genes in Escherichia coli allows bacteria to adapt to different environmental stresses. The genome of Borrelia burgdorferi encodes a single chromosomal rel gene (BB0198) (B. burgdorferi rel [rel(Bbu)]) homologous to relA and spoT of E. coli. Its role...

Topics

Animals
Bacterial Proteins
Borrelia burgdorferi
Drug Resistance, Bacterial
Guanine Nucleotides
Mice
Mutation
RNA, Messenger

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Identifiers

PMID: 16041012
DOI: 10.1128/IAI.73.8.4972-4981.2005
PMCID: PMC1201186

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