Article

The nucleotide messenger (p)ppGpp is a co-repressor of the purine synthesis transcription regulator PurR in Firmicutes

2020-12-03

Abstract excerpt

<h4>ABSTRACT</h4> The nucleotide messenger (p)ppGpp allows bacteria to adapt to fluctuating environments by reprogramming the transcriptome. Yet despite its well-recognized role in gene regulation, (p)ppGpp is only known to directly affect transcription in Proteobacteria. Here we reveal a different mechanism of gene regulation by (p)ppGpp in Firmicutes from soil bacteria to pathogens: (p)ppGpp serves as a co-repr...

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Literature Corpus work: a896f422-eeb3-50a0-b2d1-49f8c5a93e6e
DOI: 10.1101/2020.12.02.409011

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