Article
Lowering GTP level increases survival of amino acid starvation but slows growth rate for Bacillus subtilis cells lacking (p)ppGpp.
Journal of bacteriology - 1 Jun 2014
Bittner Alycia N, Kriel Allison, Wang Jue D
Abstract excerpt
Bacterial cells sense external nutrient availability to regulate macromolecular synthesis and consequently their growth. In the Gram-positive bacterium Bacillus subtilis, the starvation-inducible nucleotide (p)ppGpp negatively regulates GTP levels, both to resist nutritional stress and to maintain GTP homeostasis during growth. Here, we quantitatively investigated the relationship between GTP level, survival of...
Topics
- Amino Acids
- Bacillus subtilis
- Guanosine Pentaphosphate
- Guanosine Triphosphate
- Mutation