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Article

Degradation of ppGpp by nudix pyrophosphatase modulates the transition of growth phase in the bacterium Thermus thermophilus.

The Journal of biological chemistry - 5 Jun 2009

Ooga Takushi, Ohashi Yoshiaki, Kuramitsu Seiki, Koyama Yoshinori, Tomita Masaru, Soga Tomoyoshi, Masui Ryoji

Abstract excerpt

A major bacterial alarmone, guanosine 3',5'-bispyrophosphate (ppGpp), controls cellular growth under conditions of nutritional starvation. For most bacteria, intracellular ppGpp levels are tightly controlled by the synthesis/degradation cycle of RelA and SpoT activities. This study shows a novel ppGpp regulatory protein governing the cellular growth of Thermus thermophilus, Ndx8, a member of the Nudix...

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Identifiers

PMID: 19346251
DOI: 10.1074/jbc.M900582200
PMCID: PMC2708851

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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