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Article

Stochastic induction of persister cells by HipA through (p)ppGpp-mediated activation of mRNA endonucleases.

Proceedings of the National Academy of Sciences of the United States of America - 21 Apr 2015

Germain Elsa, Roghanian Mohammad, Gerdes Kenn, Maisonneuve Etienne

Abstract excerpt

The model organism Escherichia coli codes for at least 11 type II toxin-antitoxin (TA) modules, all implicated in bacterial persistence (multidrug tolerance). Ten of these encode messenger RNA endonucleases (mRNases) inhibiting translation by catalytic degradation of mRNA, and the 11th module, hipBA, encodes HipA (high persister protein A) kinase, which inhibits glutamyl tRNA synthetase (GltX). In turn,...

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Identifiers

PMID: 25848049
DOI: 10.1073/pnas.1423536112
PMCID: PMC4413331

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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