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Article

Specification of hematopoietic and vascular development by the bHLH transcription factor SCL without direct DNA binding.

Development (Cambridge, England) - 1 Oct 1999

Porcher C, Liao E C, Fujiwara Y, Zon L I, Orkin S H

Abstract excerpt

Transcription factors, such as those of the basic-helix-loop-helix (bHLH) and homeodomain classes, are primary regulators of cell fate decisions and differentiation. It is considered axiomatic that they control their respective developmental programs via direct binding to cognate DNA sequences in critical targets genes. Here we test this widely held paradigm by in vivo functional assay of the leukemia oncoprotein...

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Identifiers

PMID: 10498694
DOI: 10.1242/dev.126.20.4603

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Specification of hematopoietic and vascular development by the bHLH transcription factor SCL without direct DNA binding.PMID 10498694Read ↗

Differential use of SCL/TAL-1 DNA-binding domain in developmental hematopoiesisSemantic proximity Read ↗

Rescue of the lethal scl(-/-) phenotype by the human SCL locus.Semantic proximity Read ↗

Decoding hematopoietic specificity in the helix-loop-helix domain of the transcription factor SCL/Tal-1.Semantic proximity Read ↗

Distinct roles for SCL in erythroid specification and maturation in zebrafish.Semantic proximity Read ↗

The paralogous hematopoietic regulators Lyl1 and Scl are coregulated by Ets and GATA factors, but Lyl1 cannot rescue the early Scl-/- phenotype.Semantic proximity Read ↗

Distinct Functions for Different scl Isoforms in Zebrafish Primitive and Definitive HematopoiesisSemantic proximity Read ↗

Long-range comparison of human and mouse SCL loci: localized regions of sensitivity to restriction endonucleases correspond precisely with peaks of conserved noncoding sequences.Semantic proximity Read ↗

Cloche is a bHLH-PAS transcription factor that drives haemato-vascular specification.Semantic proximity Read ↗

Transcriptional Regulation of the SCL Locus: Identification of an Enhancer That Targets the Primitive Erythroid Lineage In VivoSemantic proximity Read ↗

Absence of yolk sac hematopoiesis from mice with a targeted disruption of the scl gene.Semantic proximity Read ↗

Definitive hematopoiesis requires Runx1 C-terminal-mediated subnuclear targeting and transactivation.Semantic proximity Read ↗

The SCL Gene Is Formed from a Transcriptionally Complex LocusSemantic proximity Read ↗

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