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Article

Distinct roles for SCL in erythroid specification and maturation in zebrafish.

The Journal of biological chemistry - 16 Dec 2005

Juarez Marianne A, Su Fengyun, Chun Sang, Kiel Mark J, Lyons Susan E

Abstract excerpt

The stem cell leukemia (SCL) transcription factor is essential for vertebrate hematopoiesis. Using the powerful zebrafish model for embryonic analysis, we compared the effects of either reducing or ablating Scl using morpholino-modified antisense RNAs. Ablation of Scl resulted in the loss of primitive and definitive hematopoiesis, consistent with its essential role in these processes. Interestingly, in embryos...

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Identifiers

PMID: 16210319
DOI: 10.1074/jbc.M507998200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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