Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Decoding hematopoietic specificity in the helix-loop-helix domain of the transcription factor SCL/Tal-1.

Molecular and cellular biology - 1 Sept 2004

Schlaeger Thorsten M, Schuh Anna, Flitter Simon, Fisher Andreas, Mikkola Hanna, Orkin Stuart H, Vyas Paresh, Porcher Catherine

Abstract excerpt

The helix-loop-helix (HLH) domain is employed by many transcription factors that control cell fate choice in multiple developmental settings. Previously, we demonstrated that the HLH domain of the class II basic HLH (bHLH) protein SCL/Tal-1 is critical for hematopoietic specification. We have now identified residues in this domain that are essential for restoring hematopoietic development to SCL-/- embryonic stem...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Helix-Loop-Helix Motifs
Share to Hematopoiesis

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to LIM Domain Proteins

Share to Macromolecular Substances

Share to Metalloproteins

Share to Multiprotein Complexes

Share to Phenylalanine

Share to T-Cell Acute Lymphocytic Leukemia Protein 1

Source

Open in PubMed Open full text

Identifiers

PMID: 15314159
DOI: 10.1128/MCB.24.17.7491-7502.2004
PMCID: PMC506978

Genes

LMO2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Decoding hematopoietic specificity in the helix-loop-helix domain of the transcription factor SCL/Tal-1.PMID 15314159Read ↗

Differential use of SCL/TAL-1 DNA-binding domain in developmental hematopoiesisSemantic proximity Read ↗

Specification of hematopoietic and vascular development by the bHLH transcription factor SCL without direct DNA binding.Semantic proximity Read ↗

Structural basis for LMO2-driven recruitment of the SCL:E47bHLH heterodimer to hematopoietic-specific transcriptional targets.Semantic proximity Read ↗

Distinct Functions for Different scl Isoforms in Zebrafish Primitive and Definitive HematopoiesisSemantic proximity Read ↗

Enhancer-Binding Activity of the tal-1 Oncoprotein in Association with the E47/E12 Helix-Loop-Helix ProteinsSemantic proximity Read ↗

Genes, proteins and complexes: the multifaceted nature of FHL family proteins in diverse tissues.Semantic proximity Read ↗

Enhancer-binding activity of the tal-1 oncoprotein in association with the E47/E12 helix-loop-helix proteins.Semantic proximity Read ↗

The TAL1/Scl basic helix-loop-helix protein blocks myogenic differentiation and E-box dependent transactivation.Semantic proximity Read ↗

The multifunctional roles of the four-and-a-half-LIM only protein FHL2Semantic proximity Read ↗

LIM-homeodomain genes in mammalian development and human disease.Semantic proximity Read ↗

SCL/TAL1 expression level regulates human hematopoietic stem cell self-renewal and engraftment.Semantic proximity Read ↗

Structure of a dominant-negative helix-loop-helix transcriptional regulator suggests mechanisms of autoinhibition.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.