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Article

Differential use of SCL/TAL-1 DNA-binding domain in developmental hematopoiesis

13 Jun 2008

Abstract excerpt

Dissecting the molecular mechanisms used by developmental regulators is essential to understand tissue specification/differentiation. SCL/TAL-1 is a basic helix-loop-helix transcription factor absolutely critical for hematopoietic stem/progenitor cell specification and lineage maturation. Using in vitro and forced expression experimental systems, we previously suggested that SCL might have DNA-binding-independent...

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Identifiers

PMID: 18550854
DOI: 10.1182/blood-2007-12-128900

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