Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Distinct Functions for Different scl Isoforms in Zebrafish Primitive and Definitive Hematopoiesis

27 Apr 2007

Abstract excerpt

The stem-cell leukemia (SCL, also known as TAL1) gene encodes a basic helix-loop-helix transcription factor that is essential for the initiation of primitive and definitive hematopoiesis, erythrocyte and megakarocyte differentiation, angiogenesis, and astrocyte development. Here we report that the zebrafish produces, through an alternative promoter site, a novel truncated scl (tal1) isoform, scl-beta, which...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aquaculture disease management and microbiota
Share to Erythrocyte Function and Pathophysiology
Share to Zebrafish Biomedical Research Applications

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 17472439
DOI: 10.1371/journal.pbio.0050132

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Distinct Functions for Different scl Isoforms in Zebrafish Primitive and Definitive HematopoiesisPMID 17472439Read ↗

The T cell leukemia oncoprotein SCL/tal-1 is essential for development of all hematopoietic lineages.Semantic proximity Read ↗

Distinct roles for SCL in erythroid specification and maturation in zebrafish.Semantic proximity Read ↗

Differential use of SCL/TAL-1 DNA-binding domain in developmental hematopoiesisSemantic proximity Read ↗

SCL/TAL1 expression level regulates human hematopoietic stem cell self-renewal and engraftment.Semantic proximity Read ↗

Transcriptional Regulation of the SCL Locus: Identification of an Enhancer That Targets the Primitive Erythroid Lineage In VivoSemantic proximity Read ↗

Characterization of DNA-binding-dependent and -independent functions of SCL/TAL1 during human erythropoiesis.Semantic proximity Read ↗

SUMO1-activating enzyme subunit 1 is essential for the survival of hematopoietic stem/progenitor cells in zebrafish.Semantic proximity Read ↗

Zebrafish as a model for leukemia and other hematopoietic disordersSemantic proximity Read ↗

The paralogous hematopoietic regulators Lyl1 and Scl are coregulated by Ets and GATA factors, but Lyl1 cannot rescue the early Scl-/- phenotype.Semantic proximity Read ↗

Regulation of stem cells in the zebra fish hematopoietic system.Semantic proximity Read ↗

Runx transcription factors in the development and function of the definitive hematopoietic system.Semantic proximity Read ↗

Transcription factor SCL/TAL1 mediates the phosphorylation of MEK/ERK pathway in umbilical cord blood CD34⁺ stem cells during hematopoietic differentiation.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.