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Article

The SCL Gene Is Formed from a Transcriptionally Complex Locus

1 Dec 1990

Abstract excerpt

We describe the structural organization of the human SCL gene, a helix-loop-helix family member which we believe plays a fundamental role in hematopoietic differentiation. The SCL locus is composed of eight exons distributed over 16 kb. SCL shows a pattern of expression quite restricted to early hematopoietic tissues, although in malignant states expression of the gene may be somewhat extended into later...

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Identifiers

PMID: 2247063
DOI: 10.1128/mcb.10.12.6426-6435.1990

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Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

The SCL Gene Is Formed from a Transcriptionally Complex LocusPMID 2247063Read ↗

Transcriptional Regulation of the SCL Locus: Identification of an Enhancer That Targets the Primitive Erythroid Lineage In VivoSemantic proximity Read ↗

Disruption of the Human SCL Locus by "Illegitimate" V-(D)-J Recombinase ActivitySemantic proximity Read ↗

Molecular cloning and chromosomal localization of the murine homolog of the human helix-loop-helix gene SCL.Semantic proximity Read ↗

Long-range comparison of human and mouse SCL loci: localized regions of sensitivity to restriction endonucleases correspond precisely with peaks of conserved noncoding sequences.Semantic proximity Read ↗

Rescue of the lethal scl(-/-) phenotype by the human SCL locus.Semantic proximity Read ↗

Involvement of the putative hematopoietic transcription factor SCL in T-cell acute lymphoblastic leukemia.Semantic proximity Read ↗

The paralogous hematopoietic regulators Lyl1 and Scl are coregulated by Ets and GATA factors, but Lyl1 cannot rescue the early Scl-/- phenotype.Semantic proximity Read ↗

Absence of yolk sac hematopoiesis from mice with a targeted disruption of the scl gene.Semantic proximity Read ↗

Differential use of SCL/TAL-1 DNA-binding domain in developmental hematopoiesisSemantic proximity Read ↗

Specification of hematopoietic and vascular development by the bHLH transcription factor SCL without direct DNA binding.Semantic proximity Read ↗

An scl gene product lacking the transactivation domain induces bony abnormalities and cooperates with LMO1 to generate T-cell malignancies in transgenic mice.Semantic proximity Read ↗

Adult hematopoietic stem and progenitor cells require either Lyl1 or Scl for survival.Semantic proximity Read ↗

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