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Article

Absence of yolk sac hematopoiesis from mice with a targeted disruption of the scl gene.

Proceedings of the National Academy of Sciences of the United States of America - 18 Jul 1995

Robb L, Lyons I, Li R, Hartley L, Köntgen F, Harvey R P, Metcalf D, Begley C G

Abstract excerpt

The scl gene encodes a basic-helix-loop-helix transcription factor which was identified through its involvement in chromosomal translocations in T-cell leukemia. To elucidate its physiological role, scl was targeted in embryonic stem cells. Mice heterozygous for the scl null mutation were intercrossed and their offspring were genotyped. Homozygous mutant (scl-/-) pups were not detected in newborn litters, and...

Topics

Animals
Aorta
Base Sequence
Basic Helix-Loop-Helix Transcription Factors
Cells, Cultured
DNA-Binding Proteins
Embryo, Mammalian
Genes, Lethal
Genotype
Helix-Loop-Helix Motifs

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Hematopoiesis, Extramedullary

Homozygote

Mice

Mice, Inbred C57BL

Mice, Mutant Strains

Molecular Sequence Data

Mutation

Polymerase Chain Reaction

Source

Open in PubMed Open full text

Identifiers

PMID: 7624372
DOI: 10.1073/pnas.92.15.7075
PMCID: PMC41474

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7624372-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Absence of yolk sac hematopoiesis from mice with a targeted disruption of the scl gene.PMID 7624372Read ↗

The scl gene product is required for the generation of all hematopoietic lineages in the adult mouse.Semantic proximity Read ↗

Rescue of the lethal scl(-/-) phenotype by the human SCL locus.Semantic proximity Read ↗

Adult hematopoietic stem and progenitor cells require either Lyl1 or Scl for survival.Semantic proximity Read ↗

Distinct roles for SCL in erythroid specification and maturation in zebrafish.Semantic proximity Read ↗

The T cell leukemia oncoprotein SCL/tal-1 is essential for development of all hematopoietic lineages.Semantic proximity Read ↗

The paralogous hematopoietic regulators Lyl1 and Scl are coregulated by Ets and GATA factors, but Lyl1 cannot rescue the early Scl-/- phenotype.Semantic proximity Read ↗

SCL/Tal-1 transcription factor acts downstream of cloche to specify hematopoietic and vascular progenitors in zebrafish.Semantic proximity Read ↗

Differential use of SCL/TAL-1 DNA-binding domain in developmental hematopoiesisSemantic proximity Read ↗

The SCL Gene Is Formed from a Transcriptionally Complex LocusSemantic proximity Read ↗

Tetracycline-controlled transgenic targeting from the SCL locus directs conditional expression to erythrocytes, megakaryocytes, granulocytes, and c-kit-expressing lineage-negative hematopoietic cells.Semantic proximity Read ↗

Specification of hematopoietic and vascular development by the bHLH transcription factor SCL without direct DNA binding.Semantic proximity Read ↗

Transcriptional Regulation of the SCL Locus: Identification of an Enhancer That Targets the Primitive Erythroid Lineage In VivoSemantic proximity Read ↗

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